Jan 30, · Cotrimoxazole Tablet is used to fight against any kind of bacterial infections. It also prevents and treats Urinary Tract Infections. It also prevents and treats Urinary Tract Infections. It prevents bacterial synthesis by slowing down growth and production. Sep 16, · Co-trimoxazole is a combination of a sulfonamide medicine called sulfamethoxazole, and trimethoprim, used for infection.
Cotrimoxazole Tablet is used to fight against any kind of bacterial infections. It also prevents and treats Urinary Tract Infections. It prevents bacterial synthesis by slowing down growth and production.
Cotrimoxazole tablet helps in treating pneumonia, bronchitis, infections of the ear, and abdomen bacterial infections. Do not use this medication if you are allergic to any of the ingredients present in it. Before using this tablet tell your doctor if you have or are:. Also let your doctor know your history of medical problems, pre-existing diseases and current health conditions. This medication should be taken in doses prescribed by the doctor. Dosage depends on conditions such as medical condition, dietage, and counteraction with other medicines.
Cotrimoxazole Tablet is a prescription medicine and must be taken in the dose and duration prescribed by your doctor. To ensure better efficacy, it must be taken at a fixed time and after the meal. It must not be consumed in the dose, more than prescribed.
This medication must be taken only with the consultation of the Doctor. The tablet should not be taken empty stomach. It must be taken with the food with an adequate amount of water.
Also, it must be taken at a fixed time to ensure better efficacy. Do not consume it more than the recommended dose. This tablet causes inhibition of the enzymatic alteration of pteridine and p-aminobenzoic acid PABA into dihydropteroic acid.
It competes with PABA for combining with dihydrofolate synthetase. This is an intermediate of the tetrahydrofolic acid THF synthesis. After Trimethoprim combines to dihydrofolate reductase it brings about inhibition of dihydrofolic acid DHF reduction into tetrahydrofolic acid THF.
Tetrahydrofolic acid is an important predecessor to thymidine synthesis and hindrance with the synthesis of pathway brings about inhibition of bacterial DNA synthesis.
Whenever you take more than one medicine, what is cotrimoxazole used for mix it with certain foods or beverages, you"re at risk of a drug interaction. We don't support your browser. Please upgrade your browser or download modern browsers from here!
About Health Feed. Consult Now. Common Specialities. Cotrimoxazole Tablet. Medicine composition: SulfamethoxazoleTrimethoprim. Prescription vs. OTC: Prescription by Doctor not required. About Cotrimoxazole Tablet. What are the uses of Cotrimoxazole Tablet. What are the contraindications of Cotrimoxazole Tablet? What are the side effects of Cotrimoxazole Tablet? Key highlights of Cotrimoxazole Tablet. What are the dosage instructions?
How does this medication work? What are the interactions of Cotrimoxazole Tablet? Ans: Cotrimoxazole Tablet has Sulfamethoxazole and Trimethoprim as active elements present in it.
This medicine performs its action by killing or slowing the what is cotrimoxazole used for of sensitive bacteria. Ques: What are the uses of Cotrimoxazole What is cotrimoxazole used for Ans: Cotrimoxazole Tablet is used for the treatment and prevention from conditions such as Urinary tract bacterial infections and Respiratory tract bacterial infections.
Ques: What are the instructions for storage and disposal Cotrimoxazole Tablet? Ans: Cotrimoxazole Tablet should be kept in a cool dry place and in its original packaging. Make sure this medication remains what to bring on plane to children and pets.
Ques: Can I stop taking Cotrimoxazole Tablet when my symptoms are relieved? Ans: Do not stop taking this drug if you start feeling better as doing so can result in recurring symptoms.
It is vital to complete the full course of medication to get the most out of this drug and to treat the infection completely. Ques: What if I don't get better after using the Cotrimoxazole Tablet?
Your doctor might recommend some other alternative medication or alter the dose in such a how to make crossword puzzles in excel. Ques: Can the use of Cotrimoxazole Tablet cause diarrhea? Ans: Diarrhea is one of the most common side effects of this medication. This is because this medicine basically works by killing the harmful bacteria and sometimes it interferes with the functioning of good bacteria which leads to diarrhea.
Ques: How long does Cotrimoxazole Tablet take to work? Ans: It takes about a few days for this drug to start working, however, you would start feeling better just after taking this drug.
Take this drug for the duration prescribed by the doctor to cure the infection completely. Ans: Do not take this drug if you are pregnant. Consult a doctor to know a substitute of this drug.
Ques: How does Cotrimoxazole Tablet function? Ans: The drug inhibits the production of folic acid, a compound that assists in the growth of bacteria in the body. Disclaimer: The information produced here is best of our knowledge and experience and we have tried our best to make it as accurate and up-to-date as possible, but we would like to request that it should not be treated as a substitute for professional advice, diagnosis or treatment.
Lybrate is a medium to provide our audience with the common information on medicines and does not guarantee its accuracy or exhaustiveness. Even if there is what is cotrimoxazole used for mention of a warning for any drug or combination, it never means that we what causes temporary loss of vision in one eye claiming that the drug or combination is safe for consumption without any proper consultation with an expert.
Lybrate does not take responsibility for what is cotrimoxazole used for aspect of medicines or treatments. If you have any doubts about your medication, we strongly recommend you to see a doctor immediately.
Content Details. DrxHina Firdous. PhD Pharmacology Pursuing, M. Pharma PharmacologyB. Pharma - Certificate in Nutrition and Child Care. Garima Sharma. Table of Content. FAQs about Cotrimoxazole Tablet.
About Cotrimoxazole Tablet
Jul 14, · Co-trimoxazole (combination of trimethoprim and sulphamethoxazole in a ) ratio is a Sulphur containing anti-folate bactericidal antibiotic indicated for the treatment of respiratory tract infections. It has been around for over 60 years and is inexpensive and readily available with a good safety profile. It has a rapid onset of action with. Co-trimoxazole may enhance the blood sugar lowering effect of repaglinide and sulphonylureas such as glibenclamide, gliclazide and tolbutamide that are used to treat type 2 diabetes. Dec 07, · Uses; Warnings; What to avoid; Side effects; Dosage; Interactions; What is clotrimazole? Clotrimazole is an antifungal medication. It is like an antibiotic but is used to treat yeast (fungal) infections. Oral clotrimazole is used to treat and prevent yeast infections of the mouth and throat.
Study record managers: refer to the Data Element Definitions if submitting registration or results information. Critical disease may present as acute respiratory failure secondary to Acute Respiratory Distress Syndrome ARDS and is caused by the body's hyper-immune response to the virus in the form of a cytokine storm syndrome CSS.
Co-trimoxazole combination of trimethoprim and sulphamethoxazole in a ratio is a Sulphur containing anti-folate bactericidal antibiotic indicated for the treatment of respiratory tract infections.
It has been around for over 60 years and is inexpensive and readily available with a good safety profile. It has a rapid onset of action with excellent bioavailability and lung penetration.
In addition to having antimicrobial properties co-trimoxazole have immunomodulatory and anti-inflammatory properties and may be a potential treatment option for cytokine storm syndrome mediated severe COVID After taking informed written consent patients will be randomly assigned in a ratio to either oral co-trimoxazole in addition to standard therapy or standard therapy alone. Conclusion If the results from this clinical trial demonstrate the beneficial effects of co-trimoxazole in severe COVID patients it could be used widely, thereby reducing the need for respiratory support and potentially saving thousands of lives in developing nations with limited resources where healthcare may be easily overwhelmed.
The pandemic situation in Bangladesh is also evolving rapidly with positive cases and deaths increasing each day. Epidemiological changes in COVID infection should be monitored taking into account potential routes of transmission and subclinical infections, in addition to the adaptation, evolution, and virus spread among humans and possible intermediate animals and reservoirs.
But till today there is no specific management to deal with this highly deadly viral infection. Howeverthere are few drugs which might cause some beneficial effects in the recovery of the patient.
Cotrimoxazole is a time tested antibiotic which has been in clinical use for 60 years with anti-bacterial action against a wide range of organism. In addition to the antimicrobial effects, co-trimoxazole has anti-inflammatory and immunomodulatory effects.
As in some case reports this has shown significant clinical improvement in ARDS, so there is a possibility, that cotrimoxazole might have also role in improving the clinical outcome in COVID patients especially in moderate to severe cases. As till today there is no specific treatment for COVID infections, if cotrimoxazole ifs found to be effective this will bring a great benefit to the target populations.
Beside this, cotrimoxazole is a very cheap drug in comparison to other ones this will also be of great economical benefit in taking cares of the general population. As there is no such study published about the role of cotrimoxazole in COVID patients, this study will generate a new information which bring a great benefit in battling with the COVID infection. To assess length of stay who are treated with co-trimoxazole in addition to standard treatment versus standard treatment alone.
To find out side effects rash. To find out requirement for ventilator support non-invasive and invasive ventilation who are treated with co-trimoxazole in addition to standard treatment versus standard treatment alone. To assess the mortality in patients with severe COVID who are treated with co-trimoxazole in addition to standard treatment versus standard treatment alone.
Study design:Open-label randomized controlled trial Study duration: Six months. Patients presenting to participating hospitals in Bangladesh with symptoms ofCOVID will be assessed for eligibility. Already receiving Tocilizumab or convalescent therapy Sampling procedure:This RCT will consist of two arms, experimental group and control group. Randomized case: control, non-blinded trial. The following treatments are recommended as standard therapy:. Length of stay in hospital in days 2.
In-patient mortality. Pre-designed case record form CRF will be used for collecting data, which will also contain the result of the study. The information collected in the CRF will be reviewed and inconsistencies will be investigated and clarified. Data from case record forms will be anonymised and stored securely in a secure online web-based portal.
Statistical analysis: Statistical analysis will be performed using t-test or Mann -Whitney U test or Wilcoxon signed rank test for continuous variables and Chi- square test or Fisher's exact test for categorical variables. Survival will be assessed by the Kaplan-Meier method. Comparisons between two groups will be performed using the log-rank test and Hazard regression test. The statistical software SPSS version 25 will be used for the analysis. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms x. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U.
Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Last Update Posted : July 16, See Contacts and Locations. Study Description. Show detailed description. Hide detailed description. Detailed Description:. Objectives: General Objectives To assess the clinical outcome of co-trimoxazolein patients with severe COVID Specific Objectives: To assess length of stay who are treated with co-trimoxazole in addition to standard treatment versus standard treatment alone.
Forty-seven 47 patients will be enrolled for each arm. Randomization will be done by a random number table. Allocations will be in sequentially numbered. A checklist of clinical findings A checklist of investigation findings. Arms and Interventions.
Outcome Measures. Primary Outcome Measures : Length of stay in hospital in days [ Time Frame: 14 days ] Duration of hospital stay in days. Eligibility Criteria. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.
More Information. Layout table for additonal information Responsible Party: Prof. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Drug: oral co-trimoxazole. Phase 2. Study Type :. Interventional Clinical Trial.
Estimated Enrollment :. Arm A :control group will receive standard treatment, Arm B: experimental group will receive standard care and oral co-triamoxazole. Actual Study Start Date :. Estimated Primary Completion Date :.
Estimated Study Completion Date :. Contact: Rehan Quadery. July 14, Key Record Dates. Data will be shared with the journal authority and make public as part of the publication. Available on public domain like figshare, researchgate and others.